cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2
نویسندگان
چکیده
منابع مشابه
cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2
Results Impaired mitochondrial respiration was observed in advanced stage dilative 9wk TAC hearts, associated with down-regulation of PGC1a, but not in 1-3 wk TAC hearts. Delayed sildenafil treatment (100mg/kg/day) initiated after hypertrophy establishment (1-3 wk TAC) inhibited progression of remodeling up to 9wks, which was associated with restored PGC1a expression and preserved mitochondrial...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2011
ISSN: 1471-2210
DOI: 10.1186/1471-2210-11-s1-o18